Abstract: In order to determine anti-fracture design parameters and ensure the safety of construction and operation of buildings of Xizang Zhala Hydropower Station, on the basis of mastering the data of spatial distribution and activity profile of Naozhong fault, we conducted in-depth research on the activity of Naozhong fault in the area by means of UAV aerial survey, engineering geological analogy, GPS terrain deformation monitoring, site survey and other comprehensive means. The results showed that the Naozhong fault extends from the east side of Jushui Village towards the NE direction, crosses the water diversion tunnel, and reaches near Yanjing township, with a total length of about 50 km. The fault zone was mainly characterized by right-handed strike slip movement and belongs to the Holocene active fault with long-term activity. The activity process mainly includes creep and stick slip, with creep rates of 0.12 to 0.43 mm/a. The application of UAV aerial survey technology had improved the efficiency and accuracy of work in harsh high-altitude environments. The conclusions drawn from various research methods were mutually verified, which enhanced the reliability and accuracy of research results. The research results can provide a reference for the anti-fracture design of water diversion tunnels.